The Lymphoma Immunotherapy Program at the Mount Sinai School of Medicine has an opening for a Postdoctoral Fellow available in the laboratory of Dr. Joshua Brody, Director. The position will entail a wide variety of moderately complex responsibilties including designing protocols and carrying out experiments, interpreting results, and preparing figures to convey analyses for meetings and publication. Modalities include performing cellular and molecular immunology techniques such as Flow Cytometry, ELISA, Luminex, and studies with animals as well as primary patient specimens. The lab focuses on basic and applied tumor immunology (particularly in lymphoma, melanoma, and ovarian adenocarcinoma). Other areas of interest include: bioinformatic-based collaborations tracking T-cell responses using high-throughput sequencing of the entire TCRbV repertoire and studies of small-molecule inhibitors of lymphocyte signal transduction, e.g. PI3K, mTOR, btk. Our lab has the rare opportunity to both perform correlative studies on primary patient tumor samples from early phase clinical trials and to continually develop advancements in those trials based on what is learned. The core mission is the translation of basic science in tumor immunology into novel clinical trials, e.g.:
Brody J, et al., In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol. 2010 Oct 1;28(28):4324-32.
Brody J, et al., Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors. Blood. 2009 Jan 1;113(1):85-94.
Brody J, et al., Immunotransplant for mantle cell lymphoma: Phase I/II study preliminary results. J Clin Oncol 29: 2011 (suppl; abstr 2509)
Brody J, et al., Active and passive immunotherapy for lymphoma: proving principles and improving results. J Clin Oncol. 2011 May 10;29(14):1864-75.
REQUIREMENTS:
-PhD in Immunology, Cancer Biology, or related discipline;
-Background experience and expertise in animal studies and flow cytometry.
-Minimum computer skills: Excel, Word, Powerpoint, Flow-Cytometric Analysis software
-Excellent written and verbal communication skills.
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