Postdoctoral position available to study PROGRAMMED DNA ELIMINATION in NEMATODES (Chomatin Diminution). In Ascaris, 15% of the genome is eliminated in the somatic lineages during the 3rd through 5th cleavage (4 to 16 cell stage), while the germline genome remains intact. ~700 germline and early development expressed genes are eliminated. Chromosomes break, regions are lost, and new and increased numbers of chromosomes are formed. Areas under investigation include analysis of 1) how genome regions are marked for retention or elimination, 2) how break regions are identified and the mechanism of chromosome breaks, 3) how eliminated chromosome regions are selectively lost from holocentric chromosomes, and 4) the contributions of histone modifications (including CenpA) and non-coding RNAs to DNA elimination. For a recent paper, see Developmental Cell 2012. 23:1072–1080.

For additional information on the laboratory’s research and recent publications, see http://140.226.65.22/Davis_lab/index.html

The University of Colorado School of Medicine, is located in a brand-new, state-of-the-art facility on the Anschutz Medical Campus. The Department of Biochemistry and Molecular Genetics provides an exciting, interactive and collegial scientific environment.

Denver, CO is an affordable multicultural, metropolitan city. The nearby Rocky Mountains offer a spectacular scenic backdrop and an array of outdoor recreational opportunities within a 15-minute to two-hour drive from Denver. The climate in Denver is relatively mild and dry, and Denver boasts over 300 days of sunshine per year! Winters are mild, with average daytime highs of 45 degrees; summers are warm and dry, with average daytime highs of 85 degrees.

Applicants should be curious, highly motivated, able to conduct creative, independent research, and have demonstrated scholarship through publication in internationally recognized English language journals.

Applicants should have significant experience in at least one or more of the following:

1. Epigenetics, chromatin, DNA damage/repair, or genomics

2. Mitosis, centromeres, or chromosome segregation

3. ChiP and ChiP-seq

4. Genomics and Bioinformatics

5. Non-coding RNAs and chromatin

6. Immunocytochemistry of nuclei and chromosomes including DNA and/or RNA FISH

7. Laser ablation and microinjection

8. C. elegans

Applications will be reviewed until suitable candidates are identified.

Applicants should apply by e-mail to richard.davis@ucdenver.edu

should contain:

1. A letter of application including a short description of previous research experience, goals, and interests in our research

2. Curriculum Vitae

3. Contact information for three references

4. Start date availabilityApplications

Full contact information:

Richard E. Davis, Ph.D

Dept. of Biochemistry and Molecular Genetics

University of Colorado School of Medicine

RC-1 South, RM 10121, MS 8101  12801 East 17th Ave

Aurora, CO 80045

Tel: 303-724-3226

Fax: 303-724-3215