Description:

A Postdoctoral position is available in the Research group of Prof. Dirk Bumann at the Biozentrum, Basel.
Infectious diseases are a major worldwide health concern. Current therapies have become increasingly inefficient because of emerging antimicrobial resistance, while the pipeline of new drugs is drying up. To avoid a public health emergency, the entire antibiotic research community must work together to reinvigorate research into new antibiotics. The available position will be part of the Innovative Medicines Initiative (http://www.imi.europa.eu/) project ND4BB-Translocation (http://www.imi.europa.eu/content/translocation) that will focus its efforts on identifying new ways of getting antibiotics into Gram-negative pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae and preventing them from expelling the drugs before they can take effect. Our contribution to the project will be the determination of the composition of the bacterial cell wall envelope under in vivo conditions, and utilization of these data to build quantitative in silico models for Pseudomonas drug penetration and efflux. We collaborate with multi-national groups from academia and industry.
The expertise in our group comprises multi-color high-speed FACS sorting, confocal microscopy, proteomics, metabolomics, microbial genetics, and in silico modeling (Nature 440, 303-7; Science 333,228-33). Group members include microbiologists, biochemists, chemists, pharmacologists, and software engineers. We are part of the Biozentrum that hosts numerous excellent labs with a wide and diverse range of interests and state-of-the art equipment (including FACSAria, FACS Fortessa, Leica SP5 and other confocal microscopes, automated microscopes, Orbitrap mass spec, etc).
Basel offers an exciting international community with major pharmaceutical companies, an outstanding cultural life enhanced by the close proximity of France and Germany, and abundant out-door opportunities including the Alps at a ca. 60 min train ride.

Qualification:

You hold a PhD in one of the following disciplines: microbiology, biochemistry, bioinformatics, biophysics, chemistry, pharmacology, and software engineering. You have an interest in systems biology.
The requirements are intentionally broad as there are a number of options available, depending on the candidates.

Compensation Range:

CHF 66’000 – 78’000

How to Apply:

Please send a pdf-file containing your C.V., letter of application, and contact info for three reference letters to Anne-Cécile Hiebel: bumannstelle@unibas.ch…

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