A postdoctoral position is available immediately in the area of cancer and stem cell biology at the Perelman School of Medicine and Abramson Cancer Center of the University of Pennsylvania. The position is in the laboratory of Dr. Dev Basu in the Division of Head and Neck Surgery. Postdoctoral training and career development will be supported by close affiliation with the lab of Dr. Anil Rustgi, Chief of the Division of Gastroenterology. Dr. Rustgi leads a well-established, NCI P01-funded program in squamous cell carcinoma biology and will provide senior level mentorship for the position. Candidates are sought to join a rapidly growing translational research program focusing on oral squamous cell carcinomas. Studies will be supported by two new NIH/NIDCR grants as well as industry-sponsored collaborations. This program aims to develop novel approaches to targeting the tumor cell subpopulations within oral cancer that are innately resistant to current therapies. Studies will emphasize rigorous molecular and functional definition of stem cell-like subpopulations and pursue detailed understanding of signaling mechanisms involved in their homeostasis. Work will rely upon our lab’s experience in 3-dimensional in vitro cancer models and in vivo xenografts, in addition to heavily utilizing patient-derived tumor specimens. Significant prior training in stem cell biology, epigenetics, cancer biology, cell biology, or biochemistry is strongly desirable.
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