Postdoctoral Fellow

Location: Grenoble, France
Staff Category: Postdoctoral Fellow
Contract Duration: 1 year
Grading: NA
Closing Date: 15 October 2014
Reference Number: GR_00067

Job Description

The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Grenoble (France), Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).

The Berger laboratory at the European Molecular Biology Laboratory (EMBL) Grenoble, France seeks to recruit an outstanding postdoctoral scientist in structural biology with a research focus directed towards the structure of macromolecular assemblies. The major theme within the group is the structural molecular biology of multiprotein complexes in human gene expression (Bieniossek et al., Nature 2013; Barford et al, COSB 2013; Imasaki et al., Nature 2011). For this purpose, we are also very active in the development and implementation of advanced recombinant expression technologies (MultiBac, ACEMBL; Fitzgerald et al. Nature Methods 2006; Bieniossek et al. Nature Methods 2009; Kriz et al., Nature Communications 2010; Bieniossek et al, TiBS 2012). Notably our MultiBac technology is our unique asset for producing large multisubunit complexes and solving their structure . Highly purified proteins and complexes are available in the laboratory. Information about our work can be obtained from http://www.embl.fr/research/unit/berger/index.html.

Qualifications and Experience

This position requires a Ph.D. in biochemistry or a related field, with a strong background in molecular biology and protein biochemistry. The applicant has experience in structure determination projects from start to finish, experience in expressing and purifying protein complexes and /or X-ray crystallography would be advantageous. The candidate is a highly motivated individual who enjoys working as part of a collaborative and multidisciplinary, dynamic and interactive team.

The laboratory is excellently situated in the structural biology environment at the Polygone Scientifique in Grenoble. Access to synchrotron X-ray radiation (ESRF), to modern biophysical instrumentation (surface plasmon resonance, dynamic light scattering, isothermal calorimetry, analytical ultracentrifugation), and to electron microscopy is provided. Complementary collaborations with leading laboratories in the field are in place.

e.g.:

- The ideal candidate should hold a PhD in biochemistry, molecular biology, structural biology or similar.
- Experience with or knowledge of molecular cloning and protein expression is required.
- Furthermore, the successful candidate should have expertise in X-ray or NMR structure determination.
- The candidate will be expected to integrate successfully into an interdisciplinary and international team.
 
We are looking for a candidate with excellent organizational, presentation, communication and interpersonal skills. Fluency in English is required.

Application Instructions

Please apply online through our website by clicking 'Apply now'.

Additional Information

An initial contract of 1 year(s) will be offered to the successful candidate. This can be renewed, depending on the circumstances at the time of review
 
Further information on the position can be obtained from Imre Berger (iberger[at]embl.fr).
 
EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.

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