Postdoctoral/Associate positions available on the molecular/cell biology of neurodegeneration and Alzheimer’s disease (AD). Emphasis on roles of presenilin/γ-secretase and familial AD ( FAD ) mutants on neuroprotection, receptor processing/signaling and synapse function. Effects of FAD mutants on APP processing and Abeta. Candidates may also work on identifying specific inhibitors of γ-secretase APP cleavage without affecting other substrates. Experience with animal models, primary neuronal cultures, neuroprotection and neuronal gene expression preferable. Relevant literature: Marambaud et al, (2003) Cell 114, 635; Georgakopoulos et al, (2006) EMBO J. 25, 1242; Baki et al, (2008) J. Neurosci. 28, 483; Barthet et al., (2013) Neurobiol. Aging 34: 499; Bruban et al., (2015) FASEB J. 29, 3702; Warren (2018) Cell Mol Life Sci. in press. Contact: N.K. Robakis, Icahn School of Medicine, Mount Sinai. One Gustave Levy Pl. New York, NY 10029. E-mail: nikos.robakis@mssm.edu …
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