Postdoctoral Fellow Opportunity – Cold Spring Harbor Laboratory – Long Island, NY

Our laboratory is seeking a highly motivated post-doctoral fellow with strong skills in functional genomics and cancer biology. Our team is comprised of experimental and computational researchers developing innovative in situ and single-cell DNA and RNA sequencing technologies in intact cells and tissues. Our goal is to isolate, image, and spatially characterize single cells based on their genetic or epigenetic signatures. We are currently investigating the role of small RNAs in regulating the rDNA loci during stem cell quiescence and how cell-cell interactions influence the exit from quiescence in development, aging, and cancer.

We are looking for a candidate interested in studying disseminated quiescent/dormant cancer cells in mouse and human tissues, including microenvironmental gene expression signatures and the T-cell receptor repertoire. The candidate will spatially reconstruct the disseminated cancer cell history using somatic mutations or T-cell receptor sequences in mouse and human pancreatic cancer specimens from our collaborators at CSHL. The candidate will be co-mentored by Professor Doug Fearon on tumor immunology. The candidate will also work with clinicians and computational collaborators on modeling tumor evolution and assist in experimental validation efforts

Position Requirements

Education: The applicant is expected to be in the process of completing or have recently completed a PhD degree in cancer biology/genomics or related areas.

Experience/Skills: The candidate should have a strong background in cancer or molecular biology and interested in developing or utilizing single-cell or spatial sequencing technologies using mouse/human disease models. Experience in R programming or biostatistics is highly desirable, and the candidate must demonstrate fluency in working with high-dimensional datasets. The candidate will be trained in our spatial sequencing techniques for detecting somatic mutations and transcriptional signatures, microscopy, and data visualization. The candidate should be curious and stimulated by challenging problems and new experimental approaches.

Cold Spring Harbor Laboratory offers a highly collaborative social and scientific environment as well as a competitive salary and benefits in a beautiful location about one hour from New York City.

Founded in 1890, CSHL has helped shape contemporary biomedical research and education with today’s research endeavors encompassing cancer, neuroscience, plant biology and quantitative biology. CSHL is a private, not-for-profit institution in New York with its own graduate school program. CSHL’s multidisciplinary scientific community is bolstered by more than 600 researchers and its Scientific Meetings & Courses Program. Post-docs are encouraged to attend renowned CSHL courses (https://meetings.cshl.edu/courseshome.aspx) and interact with the CSHL meeting attendees throughout the year (https://meetings.cshl.edu/meetingshome.aspx).

Interested individuals should send their C.V., cover letter, and a list of three referees to jlee@cshl.edu.

Je H. Lee
Assistant Professor
Cold Spring Harbor Laboratory
1 Bungtown Rd.
Cold Spring Harbor, NY 11724

In addition, the applications should submit an online application here: http://cshl.peopleadmin.com/postings/13825

Position Number: 02123-R

CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status.

Website: https://www.cshl.edu