招聘簡(jiǎn)介：

　　在瑞士盧加諾恩特Ospedaliero Cantonale（EOC）和意大利Svizzera大學(xué)（USI）外科學(xué)系的Giandomenica Iezzi博士的實(shí)驗(yàn)室中，可以獲得博士后職位，由Pietro Majno Hurst教授領(lǐng)導(dǎo)。

　　我們小組有興趣了解人類胃腸道癌中腫瘤免疫系統(tǒng)相互作用的動(dòng)力學(xué)及其通過(guò)腸道微生物群的調(diào)節(jié)（Cremonesi等人，腸道2018；67:1984；Governa等人，臨床癌癥研究，2017，23:3847，Amicarella等人，腸道2017，66:692）。

　　你的任務(wù)

　　候選人將在主要是結(jié)直腸癌的胃腸道癌的免疫細(xì)胞浸潤(rùn)和功能調(diào)節(jié)機(jī)制的項(xiàng)目中發(fā)揮主導(dǎo)作用。

　　他/她將設(shè)計(jì)、協(xié)助和執(zhí)行人體樣本和實(shí)驗(yàn)?zāi)Ｐ偷难芯俊?/p>

　　您的個(gè)人資料

　　需要免疫學(xué)博士學(xué)位。粘膜免疫學(xué)和/或腫瘤免疫學(xué)背景強(qiáng)者優(yōu)先。

　　所需技能：

　　-在細(xì)胞培養(yǎng)技術(shù)和細(xì)胞分析方面有豐富的經(jīng)驗(yàn)（有細(xì)菌培養(yǎng)經(jīng)驗(yàn)者優(yōu)先）；

　　-在多參數(shù)流式細(xì)胞術(shù)方面有重要經(jīng)驗(yàn)，

　　-具有基礎(chǔ)分子生物學(xué)技術(shù)和基因表達(dá)分析方面的經(jīng)驗(yàn)（需要具備分析大數(shù)據(jù)集的能力）

　　-有豐富的實(shí)驗(yàn)?zāi)Ｐ凸ぷ鹘?jīng)驗(yàn)

　　-出色的分析和組織能力

　　-良好的英語(yǔ)口頭和書(shū)面溝通能力

　　候選人應(yīng)獨(dú)立工作，并在團(tuán)隊(duì)導(dǎo)向的工作環(huán)境中與其他實(shí)驗(yàn)室成員合作。

　　我們提供

　　在一個(gè)刺激的、翻譯的和跨學(xué)科的研究環(huán)境中，與基礎(chǔ)免疫學(xué)家、臨床醫(yī)生和病理學(xué)家密切互動(dòng)，擁有有競(jìng)爭(zhēng)力的薪水的三年最低職位。

　　該實(shí)驗(yàn)室將設(shè)在貝林佐納的生物醫(yī)學(xué)研究所（IRB），可使用最先進(jìn)的技術(shù)和核心設(shè)施。

　　申請(qǐng)應(yīng)通過(guò)電子郵件提交至：giandomenica.iezzi@eoc.ch

　　請(qǐng)附上一封求職信和一份簡(jiǎn)歷，其中包括兩名裁判員的詳細(xì)信息。

　　英文原文:

　　A postdoctoral position is available in the laboratory of Dr. Giandomenica Iezzi, within the Department of Surgery, Ente Ospedaliero Cantonale (EOC) and Università della Svizzera Italiana (USI), Lugano, Switzerland, led by Prof. Pietro Majno-Hurst.

　　Our group is interested in understanding dynamics of tumor-immune system interaction in human gastrointestinal cancers and their modulation by gut microbiota (Cremonesi et al, Gut 2018; 67:1984; Governa et al, Clin Cancer Res 2017, 23:3847, Amicarella et al, Gut 2017, 66:692).

　　Your task

　　The candidate will take a leading role in projects focused on mechanisms regulating immune cell infiltration and function in gastrointestinal cancers, mainly colorectal cancer.

　　He/she will design, assist, and perform studies on human samples and in experimental models.

　　Your profile

　　PhD in immunology is required. A strong background in mucosal immunology and/or tumor immunology is preferred.

　　Required skills:

　　- Significant experience in cell culture techniques and in cell-based assays (experience with bacterial cultures is a plus);

　　- Significant experience in multi-parameter flow cytometry,

　　- Experience in basic molecular biology techniques and gene expression analysis (ability to analyze large data sets is desirable)

　　- Significant experience working with experimental models

　　- Outstanding analytical and organizational abilities

　　- Excellent verbal and written communication skills in English

　　The candidate is expected to work independently and to collaborate with other lab members in a team-oriented work environment.

　　We offer

　　A three-year minimum position, with a competitive salary, within a stimulating, translational, and interdisciplinary research environment, in close interaction with basic immunologists, clinicians and pathologists.

　　The lab will be located within the Institute of Research in Biomedicine (IRB) in Bellinzona, with access to state-of-the-art technologies and core facilities.

　　Applications should be submitted per email to: giandomenica.iezzi@eoc.ch

　　Please include a cover letter and a CV with details of 2 referees.

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