招聘簡介:

　　冷泉港的謝爾茨實(shí)驗(yàn)室正在為一個(gè)研究癌癥染色體畸變的資助項(xiàng)目尋找博士后研究人員。

　　大規(guī)�；�因劑量失衡在人類腫瘤中普遍存在。例如，超過一半的乳腺癌含有染色體臂1q的擴(kuò)增，使得這種變化在乳腺癌基因組中比TP53、BRCA1和BRCA2突變組合更常見。盡管這些非整倍體的出現(xiàn)頻率很高，但人們對它們的出現(xiàn)原因以及它們?nèi)绾斡绊懩[瘤的進(jìn)展知之甚少。

　　謝爾茨實(shí)驗(yàn)室正在探索新的基于crispr的染色體工程方法，研究基因劑量失衡在腫瘤發(fā)生中的作用。通過精確地操縱癌癥核型，我們可以發(fā)現(xiàn)特定非整倍體的獨(dú)特后果，而不存在任何其他的基因改變。這些方法揭示了非整倍體可能影響癌癥生理學(xué)的多種意想不到的方式。我們正在尋找有興趣使用這些技術(shù)的博士后，以揭示染色體畸變和染色體不穩(wěn)定如何影響癌癥的發(fā)生、耐藥性和轉(zhuǎn)移傳播。

　　英文原文：

　　The Sheltzer Lab at Cold Spring Harbor is seeking postdoctoral researchers for a funded project studying chromosomal aberrations in cancer.

　　Large-scale gene dosage imbalances are ubiquitous in human tumors. For instance, more than half of all breast cancers harbor an amplification of chromosome arm 1q, making this alteration more common in breast cancer genomes than mutations TP53, BRCA1, and BRCA2, combined. Despite the frequency of these aneuploidies, little is known about why they arise or how they affect tumor progression.

　　The Sheltzer laboratory is pioneering new CRISPR-based chromosome engineering methods to study the role that gene dosage imbalances play in tumorigenesis. By precisely manipulating cancer karyotypes, we can uncover the unique consequences of specific aneuploidies, absent any other genetic alterations. These approaches have revealed multiple unexpected ways that aneuploidy can affect cancer physiology. We are seeking postdocs who are interested in using these techniques to uncover how chromosomal aberrations and chromosomal instability can influence cancer initiation, drug resistance, and metastatic dissemination.

　　The Sheltzer Lab is a highly-collaborative environment that values rigorous research and that welcomes scientists from all backgrounds. We are located at Cold Spring Harbor Laboratory, an immersive research institute on the outskirts of New York City. Cold Spring Harbor is an NCI-designated Cancer Center, and every year over 10,000 scientists journey to Cold Spring Harbor to attend one of CSHL’s renowned Meetings and Courses.

　　More information on research conducted in the Sheltzer Lab can be found on our website at www.sheltzerlab.org.

　　CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status.

　　Interested candidates should send a cover letter and CV to sheltzer@cshl.edu. Please also apply for this this position via the CSHL website at: http://cshl.peopleadmin.com/postings/14705

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