招聘簡(jiǎn)介：

　　華盛頓大學(xué)醫(yī)學(xué)院內(nèi)分泌、代謝和脂質(zhì)研究部的Irfan Lodhi博士的實(shí)驗(yàn)室有一個(gè)博士后職位。洛迪實(shí)驗(yàn)室采用了尖端技術(shù)，如CRISPR/CAS9、下一代測(cè)序、脂質(zhì)體和蛋白質(zhì)組學(xué)。實(shí)驗(yàn)室的總體目標(biāo)是了解脂質(zhì)代謝途徑在調(diào)節(jié)能量平衡中的作用。我們特別感興趣的是被稱(chēng)為過(guò)氧化物酶體的多功能細(xì)胞器如何將脂質(zhì)輸送到離散的亞細(xì)胞間室來(lái)影響新陳代謝。在這一研究中，我們最近的研究表明過(guò)氧化物酶體衍生的脂質(zhì)調(diào)節(jié)線(xiàn)粒體動(dòng)力學(xué)和棕色脂肪介導(dǎo)的熱生成（參見(jiàn)Park等人2019年，臨床研究雜志129（2）：694-711）。有關(guān)更多信息和出版物的完整列表，請(qǐng)?jiān)L問(wèn)我們的實(shí)驗(yàn)室網(wǎng)站（www.lodilab.org）。

　　英文原文：

　　A postdoctoral position is available in the laboratory of Dr. Irfan Lodhi in the Division of Endocrinology, Metabolism & Lipid Research at Washington University School of Medicine. The Lodhi lab uses cutting-edge techniques such as CRISPR/Cas9, next-generation sequencing, lipidomics and proteomics. The overall goal of the lab is to understand the role of lipid metabolism pathways in the regulation of energy homeostasis. We are particularly interested in how the multifunctional organelles called peroxisomes channel lipids to discrete subcellular compartments to influence metabolism. In this line of investigation, our recent studies suggest that peroxisome-derived lipids regulate mitochondrial dynamics and brown fat-mediated thermogenesis (see Park et al. 2019, Journal of Clinical Investigation 129(2):694-711). For more information and a complete list of publications, please visit our lab website (www.LodhiLab.org).

　　The candidate must have a PhD in physiology, cell biology, biochemistry or a related field with strong experience in molecular biology evident by publication in reputable journals. Experience in mouse handling and surgery is desirable, but not required. Willingness to learn these techniques is preferred. Skills in independent analytical thinking, experimental design, troubleshooting, and the ability to effectively communicate with the laboratory staff and investigators are highly desired. Qualified candidates are invited to contact Dr. Irfan Lodhi (ilodhi@wustl.edu) with CV and names of three references.

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