招聘簡(jiǎn)介：

　　在多個(gè)合作項(xiàng)目中開(kāi)設(shè)博士后職位，研究apoa-i結(jié)合蛋白（aibp；請(qǐng)參閱《自然》2013，498:118-22；細(xì)胞報(bào)告2018，23（9）：2667-77；JCI Insight 2018，3（16）PII:120519；J Lipid Res.2018，59（5）：854-863），選擇性調(diào)節(jié)炎癥和炎癥中脂質(zhì)筏的蛋白質(zhì)。膽固醇超負(fù)荷細(xì)胞。加州大學(xué)圣地亞哥分校尤里·米勒實(shí)驗(yàn)室的研究是膽固醇代謝/脂質(zhì)筏、血管和神經(jīng)炎癥、神經(jīng)性疼痛和神經(jīng)變性的交叉點(diǎn)。一個(gè)項(xiàng)目是與Robert Rissman的實(shí)驗(yàn)室合作，使用細(xì)胞和小鼠模型研究AIBP在神經(jīng)炎癥和神經(jīng)變性中的保護(hù)作用。另一個(gè)項(xiàng)目是與伊琳娜·庫(kù)法列娃的實(shí)驗(yàn)室合作，重點(diǎn)研究AIBP-TLR4和AIBP載脂蛋白相互作用的結(jié)構(gòu)決定因素。成功的候選人將是一個(gè)最近的博士研究生（0-1年），具有很強(qiáng)的出版記錄，并在分子生物學(xué)、神經(jīng)元/膠質(zhì)細(xì)胞生物學(xué)、高分辨率成像和/或神經(jīng)退行性變小鼠模型方面表現(xiàn)出專業(yè)知識(shí)。這些研究人員將是一個(gè)充滿活力的研究團(tuán)體的一部分，他們將從脂質(zhì)異常、動(dòng)脈粥樣硬化、神經(jīng)炎癥、神經(jīng)性疼痛、阿爾茨海默氏癥和其他神經(jīng)退行性疾病的發(fā)展機(jī)制中獲得見(jiàn)解，并將重點(diǎn)放在將科學(xué)發(fā)現(xiàn)轉(zhuǎn)化為臨床上。請(qǐng)將求職信連同簡(jiǎn)歷和3名裁判員的姓名寄給yury miller，yumiller@ucsd.edu。

　　英文原文：

　　Open postdoctoral positions in a number of collaborative projects to study structure-function and biology of ApoA-I Binding Protein (AIBP; please refer to Nature 2013, 498:118-22; Cell Rep 2018, 23(9):2667-77; JCI Insight 2018, 3(16) pii: 120519; J Lipid Res. 2018, 59(5):854-863), the protein that selectively regulates lipid rafts in inflamed and cholesterol-overloaded cells. The research in Yury Miller’s laboratory at the University of California, San Diego is at the intersection of cholesterol metabolism/lipid rafts, vascular and neuro inflammation, neuropathic pain and neurodegeneration. One project is a collaboration with Robert Rissman’s lab to study protective role of AIBP in neuroinflammation and neurodegeneration, using cellular and mouse models. Another project, in collaboration with Irina Kufareva’s lab, focuses on structural determinants of AIBP-TLR4 and AIBP-apolipoprotein interactions. The successful candidate will be a recent PhD graduate (0-1 years) with a strong publication record and demonstrated expertise in molecular biology, neuronal/glial cell biology, high-resolution imaging and/or mouse models of neurodegeneration. The fellows will be part of a vibrant research community combining insights from mechanisms involved in the development of lipid abnormalities, atherosclerosis, neuroinflammation, neuropathic pain, Alzheimer’s and other neurodegenerative diseases, with a strong focus on translation of scientific discoveries into clinic. Please send a cover letter together with the CV and names of 3 referees to Yury Miller, yumiller@ucsd.edu.

為防止簡(jiǎn)歷投遞丟失請(qǐng)抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國(guó)博士人才網(wǎng)）