招聘簡(jiǎn)介：

　　紐約市哥倫比亞大學(xué)歐文醫(yī)學(xué)中心分子遺傳學(xué)部的Doege和Thaker實(shí)驗(yàn)室正在尋找一位具有干細(xì)胞生物學(xué)和/或神經(jīng)生物學(xué)專業(yè)知識(shí)的博士后研究科學(xué)家，以研究新型肥胖變體的分子遺傳學(xué)。我們的工作重點(diǎn)是利用下一代測(cè)序技術(shù)在患有嚴(yán)重肥胖的兒童和成人中識(shí)別罕見的基因變異，并在患者特異性多能干細(xì)胞衍生神經(jīng)元模型中進(jìn)行驗(yàn)證。Doege博士是一名干細(xì)胞生物學(xué)家，Thaker博士是一名具有計(jì)算生物學(xué)專業(yè)知識(shí)的兒科內(nèi)分泌學(xué)家。我們可以一起解決從床邊到長(zhǎng)椅的問題，把治療方法帶回床邊。合格的髁突動(dòng)物將接觸到包括干細(xì)胞生物學(xué)、單細(xì)胞和大塊RNA測(cè)序以及人類臨床研究在內(nèi)的尖端技術(shù)。

　　英文原文：

　　The Doege and Thaker labs in the Division of Molecular Genetics at Columbia University Irving Medical Center in New York City are seeking a highly motivated Postdoctoral Research Scientist with expertise in stem cell biology and/or neurobiology to study the molecular genetics of novel obesity variants. Our work focuses on identifying rare genetic variants in children and adults with severe obesity using next generation sequencing, and its validation in patient-specific pluripotent stem cell derived neuronal models. Dr. Doege is a stem-cell biologist and Dr. Thaker is a pediatric endocrinologist with expertise in computational biology. Together, we are able to take problems from the bedside to bench and bring the therapies back to the bedside. The eligible condidate will have exposure to cutting edge technologies including stem cell biology, single cell and bulk RNAsequencing as well as clinical research in humans.

　　The eligible candidate will join a highly interactive and collaborative research team that works on creation and molecular characterization of mutation-specific human stem cell-derived hypothalamic neurons. The project will focus on identifying RNAexpression profile of patient specific hypothalamic neurons intersecting with whole genome sequencing data to identify functional changes giving rise to extreme human phenotype. The postdoctoral candidate should have a strong interest in human stem cell biology and/or neurobiology. Previous expertise and/or interest in stem cell biology, next-gen sequencing technologies, and genomics is preferred, but not necessary. Motivation, strong interpersonal and communication skills including fluency in spoken and written English and excellence in scientific rigor is valued more than previous field of study. Advanced degree in Biological Sciences such as PhD or MD/PhD is required. The candidate will benefit from an interdisciplinary and collegial environment at Columbia and the vibrant and supportive atmosphere of a junior lab. Salary is competitive based on qualifications.

　　Applicants should send curriculum vitae, statement of interest, and contact information for three references to:

　　Claudia Doege

　　cad2114@cumc.columbia.edu

　　and

　　Vidhu Thaker

　　vvt2114@cumc.columbia.edu

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