招聘簡(jiǎn)介：

　　紐約哥倫比亞大學(xué)的Anacker實(shí)驗(yàn)室正在為研究應(yīng)激性精神疾病的神經(jīng)生物學(xué)機(jī)制的幾個(gè)項(xiàng)目尋找具有高度積極性的博士后研究人員。

　　我們的實(shí)驗(yàn)室研究了導(dǎo)致精神疾病的認(rèn)知和情緒行為中壓力引起的異常的神經(jīng)回路。我們正在使用早期生活壓力和成人壓力的小鼠模型來研究不同發(fā)育階段的逆境如何影響生命后期的認(rèn)知，情感行為和壓力脆弱性。為此，該實(shí)驗(yàn)室有許多轉(zhuǎn)基因小鼠品系，它們對(duì)應(yīng)激的易感性不同，這是基于海馬神經(jīng)發(fā)生或5-羥色胺能系統(tǒng)功能改變的差異。我們?cè)谧杂梢苿?dòng)的小鼠中使用頭戴式微型顯微鏡進(jìn)行體內(nèi)Ca2 +成像，以研究壓力如何影響大細(xì)胞群體內(nèi)個(gè)體神經(jīng)元的活動(dòng)，以及這些神經(jīng)元的功能活動(dòng)如何導(dǎo)致認(rèn)知障礙和焦慮。然后，我們使用光遺傳學(xué)和化學(xué)技術(shù)來實(shí)驗(yàn)性地調(diào)節(jié)應(yīng)激反應(yīng)神經(jīng)元的活動(dòng)及其對(duì)相關(guān)腦結(jié)構(gòu)的預(yù)測(cè)，從而在功能上研究介導(dǎo)應(yīng)激對(duì)認(rèn)知和焦慮影響的神經(jīng)回路。

　　英文原文：

　　The Anacker Lab at Columbia University in New York is looking for highly motivated postdoctoral researchers for several projects studying the neurobiological mechanisms of stress-induced psychiatric disorders.

　　Our laboratory studies the neural circuits underlying stress-induced abnormalities in cognitive and emotional behaviors that contribute to psychiatric disorders. We are using mouse models of early life stress and adult stress to investigate how adversity during different periods of development influences cognition, affective behavior, and stress vulnerability later in life. To do this, the lab has a number of transgenic mouse lines that differ in their vulnerability to stress, based on differences in hippocampal neurogenesis or functional alterations in the serotonergic system. We are using in vivo Ca2+ imaging with head-mounted miniature microscopes in freely moving mice to investigate how stress affects the activity of individual neurons within large cell populations, and how such changes in the functional activity of these neurons lead to cognitive impairments and anxiety. We then use optogenetics and chemogenetic techniques to experimentally regulate the activity of stress-responsive neurons and their projections to associated brain structures, to functionally investigate the neural circuits that mediate stress effects on cognition and anxiety.

　　In addition to this circuit level analysis, the lab studies the molecular mechanisms that determine neuronal activity and neural circuit function. In particular, we are using next-generation RNA sequencing and epigenetic analyses to investigate how adverse experiences during early life exert long-lasting effects on neuronal activity and neural circuit function by permanently altering gene expression in stress-susceptible brain areas.

　　Applicants should have a Ph.D. in Neuroscience or other relevant disciplines, and experience with rodent experimentation. Experience with stereotactic brain surgery, optogenetics, in vivo Ca2+ imaging and MATLAB programming is preferred. Positions are available immediately.

　　Please submit your CV with contact information for 3 references to Dr. Christoph Anacker (ca2635@cumc.columbia.edu).

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