招聘簡介：

　　突觸傳遞機制及其對神經(jīng)回路輸出的影響

　　愛荷華州愛荷華州卡弗醫(yī)學(xué)院的塞繆爾楊實驗室有一個開放的博士后職位。https://young.lab.uiowa.edu/twitter@samyounglab這個年輕的實驗室關(guān)注的是一個基本問題：突觸如何使神經(jīng)元回路傳輸廣泛多樣的信息？我們的研究成果將定義控制突觸特性如何驅(qū)動神經(jīng)元回路輸出的分子原理，這是有機體行為的基礎(chǔ)。

　　我們使用保持/mntb突觸的花萼。這個模型系統(tǒng)提供了無與倫比的機會來深入了解支持聽覺處理初始階段的突觸前機制。該實驗室采用了一種綜合方法，將新的病毒載體技術(shù)、電生理和生物物理方法、生物化學(xué)、光學(xué)和電子顯微鏡技術(shù)與轉(zhuǎn)基因小鼠結(jié)合使用。研究重點的兩個主要領(lǐng)域是快速聽覺信號的突觸前釋放機制和突觸前Cav2通道功能。

　　候選人必須擁有相關(guān)科學(xué)學(xué)科的博士學(xué)位和至少一本第一作者出版物。在實驗室使用的任何方法方面的專業(yè)知識優(yōu)先。感興趣的應(yīng)聘者應(yīng)提交簡歷、求職信和完整的聯(lián)系信息，至少三份有關(guān)以下職位@uiowa鏈接的參考資料：

　　https://jobs.uiowa.edu/postdoc/view/3128

　　英文原文：

　　Mechanisms of Synaptic transmission and Impact on Neuronal Circuit Output

　　There is an open post-doctoral position in the laboratory of Samuel Young at the University of Iowa Carver College of Medicine, Iowa City, IA. https://young.lab.uiowa.edu/ Twitter @samyounglab The Young laboratory is focused on the fundamental question: How do synapses enable neuronal circuits to transmit a wide diversity of information? Outcomes from our work will define the molecular principles that govern how synaptic properties drive neuronal circuit output, which underpins organism behavior.

　　We use the calyx of Held/MNTB synapse. This model system which provides unparalleled opportunities to gain insights into the presynaptic mechanisms that support the initial stages of auditory processing. The laboratory uses an integrated approach that centers on using novel viral vector technology, electrophysiological and biophysical methods, biochemistry, light and electron microscopy techniques in conjunction with transgenic mice. Two major areas of research focus are presynaptic release mechanisms for fast auditory signaling and presynaptic CaV2 channel function

　　Candidates must have a PhD in a related scientific discipline and at least one first author publication. Expertise in any of the approaches used in the laboratory are preferred. Interested candidates should submit their Curriculum Vitae, a cover letter and complete contact information for at least three references to the Jobs@UIOWA link below:

　　https://jobs.uiowa.edu/postdoc/view/3128

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