招聘簡介：

　　博士后助理（遺傳性耳聾研究）

　　·邁阿密大學(xué)

　　·地點(diǎn)：佛羅里達(dá)州邁阿密

　　·工作編號：7057129（參考號：R100029004）

　　·發(fā)布日期：2019年4月26日

　　·申請截止日期：開放至填寫

　　職位描述

　　劉學(xué)忠博士和他在邁阿密大學(xué)米勒醫(yī)學(xué)院的合作研究小組指導(dǎo)下的博士后職位，可用于基因/細(xì)胞/藥物治療遺傳性耳聾，包括神經(jīng)纖維瘤病II型（NF2）。

　　我們正在尋找在遺傳學(xué)、功能基因組學(xué)、分子生物學(xué)、干細(xì)胞生物學(xué)或相關(guān)學(xué)科領(lǐng)域擁有博士、醫(yī)學(xué)博士或同等學(xué)位的具有實(shí)驗(yàn)室經(jīng)驗(yàn)的杰出科學(xué)家加入我們的實(shí)驗(yàn)室，作為識別與耳聾相關(guān)的遺傳因素的項(xiàng)目的一部分，并為聽力損失的治療。這些職位提供了一個(gè)獨(dú)特而令人興奮的機(jī)會，作為一個(gè)多學(xué)科和協(xié)作團(tuán)隊(duì)的一部分，致力于開發(fā)尖端技術(shù)，研究耳聾和內(nèi)耳發(fā)育，并直接應(yīng)用于治療人類聽力損失。我們已經(jīng)在人類中發(fā)現(xiàn)了多個(gè)新的耳聾基因，并正在開發(fā)動(dòng)物模型和誘導(dǎo)多能干細(xì)胞（ipsc）系，以研究這些基因在聽力喪失發(fā)展中的作用。我們特別感興趣的是，在以下領(lǐng)域中，提出了新的生物學(xué)方法，如基于crispr的基因療法來治療遺傳疾病中的聽力損失：1）發(fā)展基因組編輯或基于aav的基因療法來挽救人類聽力損失的小鼠模型中的聽力；2）推進(jìn)使用crispr糾正疾病p的研究。使用人類耳聾患者的ips細(xì)胞進(jìn)行的過敏反應(yīng)；3）篩選和測試已獲FDA批準(zhǔn)的藥物對小鼠和人類耳聾基因缺陷細(xì)胞系和人類耳聾動(dòng)物模型的有效性的臨床前研究；4）開發(fā)新的傳遞途徑，用于在其他內(nèi)耳細(xì)胞類型中應(yīng)用crispr（支持細(xì)胞、血管紋和神經(jīng)節(jié)神經(jīng)元）用于治療不同細(xì)胞起源的聽力損失。應(yīng)聘者應(yīng)具有獨(dú)立性和高度的積極性，具有較強(qiáng)的溝通能力和批判性思維能力，并致力于團(tuán)隊(duì)合作和協(xié)作。候選人將利用動(dòng)物模型、ipsc技術(shù)和crispr基因組編輯，因此，在這些技術(shù)方面的經(jīng)驗(yàn)是可取的，盡管不是必需的。其他職責(zé)包括參與項(xiàng)目規(guī)劃、贈(zèng)款和手稿撰寫，以及指導(dǎo)更多的實(shí)驗(yàn)室初級成員。本項(xiàng)目的主要研究人員是劉學(xué)忠博士、博士生蘇珊·布蘭頓博士、凱瑟琳·沃爾茲博士和德里克·戴克肖恩博士。一個(gè)成功的候選人（博士，碩士/博士或醫(yī)學(xué)博士）應(yīng)該在分子生物學(xué)，動(dòng)物或細(xì)胞為基礎(chǔ)的疾病模型，遺傳學(xué)和基因組學(xué)，和/或神經(jīng)科學(xué)有很強(qiáng)的背景。有聽力損失或內(nèi)耳研究的經(jīng)驗(yàn)是有益的，但不是必需的。

　　英文原文：

　　Postdoctoral Associate (Genetic Deafness Research)

　　·         University of Miami

　　·         Location: Miami, FL

　　·         Job Number: 7057129 (Ref #: R100029004)

　　·         Posting Date: Apr 26, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　A postdoctoral position supervised by Dr. Xuezhong Liu and his Co-investigator team at the University of Miami Miller School of Medicine, is available to work on the application of gene-/cell-/drug-based approaches to treat genetic deafness including Neurofibromatosis type II (NF2).

　　We are looking for outstanding scientists with laboratory experience holding a PhD, MD or equivalent degree in the fields of genetics, functional genomics, molecular biology, stem cell biology or related disciplines to join our laboratory as part of a project to identify genetic factors linked to deafness and develop therapeutic strategies for the treatment of hearing loss. These positions offers an unique and exciting opportunity to work as part of a multidisciplinary and collaborative team engaged in developing cutting-edge technologies to study deafness and inner ear development with direct application for treating hearing loss in humans. We have identified multiple new deafness genes in humans and are developing animal models and induced pluripotent stem cell (iPSC) lines to study the role that these genes play in the development of hearing loss. We are particularly interested in advancing novel biological approaches such as CRISPR-based gene therapy to treat hearing loss in genetic diseases in the following areas: 1) Development of genome editing or AAV based gene therapy to rescue hearing in the mouse models of human hearing loss; 2) Advance the study of using CRISPR to correct disease phenotype using iPS cells from human deafness patients; 3) preclinical studies in screening and testing the effectiveness of already FDA-approved drugs on mouse and human deafness gene-deficient cell lines and in animal models of human deafness; 4) Development of new delivery route for application of CRISPR in other inner ear cell types (supporting cells, stria vascularis and ganglion neurons) to treat hearing loss with different cellular origins. Candidates should be independent and highly motivated with strong communication and critical thinking skills, as well as a dedication to teamwork and collaboration. Candidates will utilize animal models, iPSC technology, and CRISPR genome editing, as such, experience in these technologies is desirable although not required. Other duties will include participating in project planning, grant and manuscript writing, and the mentoring of more junior members of the laboratory. Lead investigators for this project are Drs. Xuezhong Liu MD, PhD, Susan Blanton, PhD, Katherina Walz, PhD, and Derek Dykxhoorn, PhD. A successful candidate (Ph.D, M.D/Ph.D or MD) should have a strong background in molecular biology, animal or cell-based models of disease, genetics and genomics, and/or neuroscience. Experience in hearing loss or inner ear research would be beneficial but is not required.

　　Minimum Qualifications

　　Ph.D., M.D., or other doctoral-level degree in a related field of study. Possess a strong background in molecular biology, animal, or cell-based models of disease, genetics, and genomics, and/or neuroscience. Must be independent and highly motivated with strong communication and critical thinking skills, as well as a dedication to teamwork and collaboration.

　　UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

　　Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University of Miami School of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

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