招聘簡(jiǎn)介：

　　密歇根州安阿伯大學(xué)癌癥藥物發(fā)現(xiàn)醫(yī)學(xué)化學(xué)博士后研究員

　　·密歇根大學(xué)

　　·地點(diǎn)：密歇根州安娜堡

　　·工作編號(hào)：7057223

　　·發(fā)布日期：2019年5月7日

　　·申請(qǐng)截止日期：2019年7月6日

　　職位描述

　　職位描述

　　在密歇根大學(xué)安娜堡托馬茲·切爾皮奇教授的實(shí)驗(yàn)室中，可以獲得博士后職位，以開發(fā)針對(duì)癌癥治療的小分子抑制劑。我們正在尋找積極性很高的合成有機(jī)化學(xué)家和藥物化學(xué)家加入一個(gè)全面的藥物發(fā)現(xiàn)計(jì)劃。Cierpicki博士的實(shí)驗(yàn)室正在進(jìn)行高度跨學(xué)科的研究，重點(diǎn)是新型抗癌藥物的臨床前開發(fā)，包括藥物化學(xué)、結(jié)構(gòu)生物學(xué)、生化和生物物理分析、生物和動(dòng)物研究。我們有一支強(qiáng)大的合成化學(xué)家團(tuán)隊(duì)來支持我們的藥物發(fā)現(xiàn)工作。成功的候選人將參與設(shè)計(jì)和合成作為潛在抗癌劑的小分子抑制劑靶向蛋白質(zhì)，主要關(guān)注與癌癥相關(guān)的靶向蛋白質(zhì)-蛋白質(zhì)相互作用的雜環(huán)化合物的合成。其職責(zé)將包括設(shè)計(jì)和合成現(xiàn)有引線的新類似物，以開發(fā)生物活性化合物，用于測(cè)試癌細(xì)胞和動(dòng)物。候選人必須獨(dú)立設(shè)計(jì)合成路線，解決具有挑戰(zhàn)性的合成問題，有效合成目標(biāo)分子，包括多步合成。

　　英文原文：

　　Postdoctoral Fellow in Medicinal Chemistry for Cancer Drug Discovery University of Michigan, Ann Arbor

　　·         University of Michigan

　　·         Location: Ann Arbor, MI

　　·         Job Number: 7057223

　　·         Posting Date: May 7, 2019

　　·         Application Deadline: Jul 6, 2019

　　Job Description

　　Job Description

　　Postdoctoral position is available in the laboratory of Prof. Tomasz Cierpicki, University of Michigan, Ann Arbor, to develop small molecule inhibitors for targeted therapies in cancer. We are seeking for highly motivated synthetic organic chemists and medicinal chemists to join a comprehensive drug discovery program. Dr. Cierpicki’s lab. is conducting highly interdisciplinary research focused on pre-clinical development of novel anti-cancer drugs, which covers medicinal chemistry, structural biology, biochemical and biophysical assays, biological and animal studies. We have a strong team of synthetic chemists to support our drug-discovery efforts. The successful candidate will be involved in designing and synthesis of small molecule inhibitors targeting proteins as potential anti-cancer agents with a major focus on synthesis of heterocyclic compounds targeting protein-protein interactions relevant to cancer. The duties will include design and synthesis of new analogues of existing leads to develop biologically active compounds for testing in cancer cells and animals. The candidate must be independent in designing synthetic routes, solving challenging synthetic problems, efficient in synthesizing targeted molecules, including multi-step synthesis.

　　Requirements

　　Applicant must have PhD in synthetic organic chemistry or medicinal chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems, SAR analysis. Applicant needs an expertise in using HPLC, NMR and MS for organic chemistry applications. Excellent oral and written communication skills in English are required.

　　How to apply

　　Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: tomaszc@umich.edu

　　Contact:

　　Tomasz Cierpicki, PhD, Associate Professor

　　Department of Pathology, University of Michigan

　　Ann Arbor, MI, 48109, USA

　　https://www.pathology.med.umich.edu/index.php?t=page&id=1473

　　e-mail: tomaszc@umich.edu

　　Relevant publications:

　　1. Borkin, D. et al, Complexity of blocking bivalent protein-protein interactions: development of a highly potent

　　inhibitor of the menin-Mixed Lineage Leukemia interaction, J. Med. Chem. 2018, 61(11): 4832.

　　2. Borkin D. et al, Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-

　　Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016, 59(3): 892-913.

　　3. Borkin, D. et al., Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in

　　vivo, Cancer Cell, 2015, 27 (4), 589-602.

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