招聘簡(jiǎn)介：

　　博士后助理（眼科-藥物發(fā)現(xiàn)/開(kāi)發(fā)）

　　·邁阿密大學(xué)

　　·地點(diǎn)：佛羅里達(dá)州邁阿密

　　·工作編號(hào)：7057369（參考號(hào)：R100030943）

　　·發(fā)布日期：2019年5月20日

　　·申請(qǐng)截止日期：開(kāi)放至填寫(xiě)

　　職位描述

　　邁阿密大學(xué)米勒醫(yī)學(xué)院巴斯科-帕爾默眼科研究所的眼科正在尋找兩名積極的博士后助理，他們?cè)诜肿?細(xì)胞生物學(xué)和動(dòng)物研究方面具有豐富的研究經(jīng)驗(yàn)，有助于發(fā)現(xiàn)和開(kāi)發(fā)生物藥物。這些職位是美國(guó)國(guó)立衛(wèi)生研究院資助的在巴斯科姆帕爾默眼科研究所開(kāi)發(fā)新型藥物療法的項(xiàng)目的一部分�！睹绹�(guó)新聞與世界報(bào)道》（U.S.News and World Report）連續(xù)15年（2004-2018年）將巴斯科姆帕爾默眼科研究所列為1眼科醫(yī)院。

　　研究將集中于開(kāi)發(fā)下一代針對(duì)各種血管疾病的靶向抗血管生成療法。實(shí)驗(yàn)室最近開(kāi)發(fā)了唯一一種具有廣泛適用性的配體組學(xué)技術(shù)，以發(fā)現(xiàn)不同疾病（包括但不限于血管生成性疾�。┑男炉煼ǖ母哔|(zhì)量藥物靶點(diǎn)（PMID:29326083）。利用這項(xiàng)強(qiáng)大的技術(shù)，我們發(fā)現(xiàn)了非常有希望的藥物靶點(diǎn)，并正在開(kāi)發(fā)針對(duì)各種眼部血管疾病的靶點(diǎn)抗血管生成療法（PMID:28330905）。該項(xiàng)目將在不同階段對(duì)候選藥物進(jìn)行調(diào)查。這些包括動(dòng)物模型中治療血管生成性疾病的人源化抗體的特征描述，體外和體內(nèi)新藥物靶點(diǎn)的分析，以及發(fā)現(xiàn)其他未知藥物靶點(diǎn)的配體組學(xué)篩選。研究活動(dòng)包括配體組學(xué)分析、分子和細(xì)胞研究、蛋白質(zhì)分析、抗體表征、受體識(shí)別和表征、治療血管滲漏和動(dòng)物模型病理性新生血管的療法、臨床前毒理學(xué)和藥代動(dòng)力學(xué)研究。

　　英文原文：

　　Postdoctoral Associate (Ophthalmology - Drug Discovery/Development)

　　·         University of Miami

　　·         Location: Miami, FL

　　·         Job Number: 7057369 (Ref #: R100030943)

　　·         Posting Date: May 20, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The Department of Ophthalmology at the Bascom-Palmer Eye Institute, University of Miami Miller School of Medicine is searching for two highly-motivated Postdoctoral Associates with strong research experience in molecular/cellular biology and animal research for biological drug discovery and development. These positions are part of NIH-funded projects to develop novel drug therapies at Bascom Palmer Eye Institute. Bascom Palmer Eye Institute has been ranked as the #1 eye hospital in the past 15 consecutive years (2004 -2018) by U.S. News and World Report.

　　Research will focus on developing next-generation targeted anti-angiogenic therapies for various vascular diseases. The laboratory recently developed the only technology of ligandomics with broad applicability to discover high-quality drug targets for novel therapies of different diseases, including but not limited to angiogenic diseases (PMID: 29326083). Using this powerful technology, we discovered highly promising drug targets and are developing targeted anti-angiogenic therapies for various ocular vascular diseases (PMID: 28330905). This project will investigate drug candidates in various stages. These include characterization of humanized antibodies to treat angiogenic diseases in animal models, analysis of novel drug targets in vitro and in vivo, and ligandomics screening to discover additional unknown drug targets. The research activities include ligandomics analysis, molecular and cellular studies, protein analyses, antibody characterizations, receptor identification and characterization, therapies to treat vascular leakage and pathological neovascularization in animal models, preclinical toxicology and pharmacokinetics studies.

　　Minimum Qualifications

　　Candidates must have a Ph.D. and/or MD, have productive scientific contributions through publication of high impact peer-reviewed papers, and show strong commitment to science. Applicants with advanced skills in molecular biology, cell biology, protein biochemistry, immunohistochemistry and animal research are highly desired. Experience in bioinformatics analysis is a plus. Excellent verbal and written communication skills are required. This position represents an excellent opportunity for career development in disease mechanism research and drug target discovery.

　　If interested, please complete an online application and send a CV, 1-2 page summary/Cover letter describing past accomplishments and 3 references, including contact information to Dr. Wei Li at w.li@med.miami.edu. Salary is based on NIH recommendation. Positions are available immediately.

　　UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

　　Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University of Miami School of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

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