招聘簡介：

　　密歇根大學(xué)安娜堡分校癌癥藥物發(fā)現(xiàn)藥物化學(xué)博士后研究員

　　·密歇根大學(xué)

　　·地點(diǎn)：密歇根州安娜堡

　　·工作號(hào)碼：7057223

　　·發(fā)布日期：2019年5月7日

　　·申請截止日期：2019年7月6日

　　職位描述

　　職位描述

　　博士后職位可在密歇根大學(xué)安娜堡分校的Tomasz Cierpicki教授的實(shí)驗(yàn)室中獲得，以開發(fā)用于癌癥靶向治療的小分子抑制劑。我們正在尋找具有高度積極性的合成有機(jī)化學(xué)家和藥物化學(xué)家加入全面的藥物發(fā)現(xiàn)計(jì)劃。 Cierpicki博士的實(shí)驗(yàn)室。正在進(jìn)行高度跨學(xué)科的研究，重點(diǎn)是新型抗癌藥物的臨床前開發(fā)，包括藥物化學(xué)，結(jié)構(gòu)生物學(xué)，生物化學(xué)和生物物理分析，生物學(xué)和動(dòng)物研究。我們擁有一支強(qiáng)大的合成化學(xué)家團(tuán)隊(duì)，以支持我們的藥物發(fā)現(xiàn)工作。成功的候選人將參與設(shè)計(jì)和合成靶向蛋白質(zhì)的小分子抑制劑作為潛在的抗癌劑，主要關(guān)注合成靶向與癌癥相關(guān)的蛋白質(zhì) - 蛋白質(zhì)相互作用的雜環(huán)化合物。職責(zé)包括設(shè)計(jì)和合成現(xiàn)有線索的新類似物，以開發(fā)用于癌細(xì)胞和動(dòng)物測試的生物活性化合物。候選人必須獨(dú)立設(shè)計(jì)合成路線，解決具有挑戰(zhàn)性的合成問題，有效合成目標(biāo)分子，包括多步合成。

　　英文原文：

　　Postdoctoral Fellow in Medicinal Chemistry for Cancer Drug Discovery University of Michigan, Ann Arbor

　　·         University of Michigan

　　·         Location: Ann Arbor, MI

　　·         Job Number: 7057223

　　·         Posting Date: May 7, 2019

　　·         Application Deadline: Jul 6, 2019

　　Job Description

　　Job Description

　　Postdoctoral position is available in the laboratory of Prof. Tomasz Cierpicki, University of Michigan, Ann Arbor, to develop small molecule inhibitors for targeted therapies in cancer. We are seeking for highly motivated synthetic organic chemists and medicinal chemists to join a comprehensive drug discovery program. Dr. Cierpicki’s lab. is conducting highly interdisciplinary research focused on pre-clinical development of novel anti-cancer drugs, which covers medicinal chemistry, structural biology, biochemical and biophysical assays, biological and animal studies. We have a strong team of synthetic chemists to support our drug-discovery efforts. The successful candidate will be involved in designing and synthesis of small molecule inhibitors targeting proteins as potential anti-cancer agents with a major focus on synthesis of heterocyclic compounds targeting protein-protein interactions relevant to cancer. The duties will include design and synthesis of new analogues of existing leads to develop biologically active compounds for testing in cancer cells and animals. The candidate must be independent in designing synthetic routes, solving challenging synthetic problems, efficient in synthesizing targeted molecules, including multi-step synthesis.

　　Requirements

　　Applicant must have PhD in synthetic organic chemistry or medicinal chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems, SAR analysis. Applicant needs an expertise in using HPLC, NMR and MS for organic chemistry applications. Excellent oral and written communication skills in English are required.

　　How to apply

　　Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: tomaszc@umich.edu

　　Contact:

　　Tomasz Cierpicki, PhD, Associate Professor

　　Department of Pathology, University of Michigan

　　Ann Arbor, MI, 48109, USA

　　https://www.pathology.med.umich.edu/index.php?t=page&id=1473

　　e-mail: tomaszc@umich.edu

　　Relevant publications:

　　1. Borkin, D. et al, Complexity of blocking bivalent protein-protein interactions: development of a highly potent

　　inhibitor of the menin-Mixed Lineage Leukemia interaction, J. Med. Chem. 2018, 61(11): 4832.

　　2. Borkin D. et al, Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-

　　Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016, 59(3): 892-913.

　　3. Borkin, D. et al., Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in

　　vivo, Cancer Cell, 2015, 27 (4), 589-602.

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