招聘簡(jiǎn)介：

　　生物醫(yī)學(xué)科學(xué)：密歇根大學(xué)安娜堡分校癌癥生物學(xué)博士后研究員

　　·密歇根大學(xué)

　　·地點(diǎn)：密歇根州安娜堡

　　·工作號(hào)碼：7057183

　　·發(fā)布日期：2019年5月2日

　　·申請(qǐng)截止日期：2019年7月2日

　　職位描述

　　描述：

　　密歇根大學(xué)安娜堡分校的Jolanta Grembecka實(shí)驗(yàn)室可以獲得生物醫(yī)學(xué)科學(xué)的博士后職位，開(kāi)展一項(xiàng)跨學(xué)科項(xiàng)目，研究小分子在體外和體內(nèi)癌癥模型中的作用，并利用目標(biāo)驗(yàn)證研究進(jìn)行遺傳方法。我們正在尋找一位在癌細(xì)胞生物學(xué)方面具有豐富經(jīng)驗(yàn)的高度積極的博士后研究員。該研究將集中于評(píng)估阻斷表觀遺傳蛋白在癌癥中的新型小分子的活性和作用機(jī)制。這一職位需要細(xì)胞生物學(xué)和分子生物學(xué)技術(shù)方面的專(zhuān)業(yè)知識(shí)，包括PCR，qRT-PCR，Western Blotting，共免疫沉淀，ChIP，ChIPSeq，流式細(xì)胞術(shù)，熒光顯微鏡，免疫染色。需要具有動(dòng)物例如轉(zhuǎn)基因小鼠和癌癥的異種移植模型的先前工作經(jīng)驗(yàn)。成功的候選人將成為跨學(xué)科團(tuán)隊(duì)的一員，專(zhuān)注于新型抗癌候選藥物的開(kāi)發(fā)和臨床前評(píng)估。

　　英文原文：

　　Biomedical Science: Postdoctoral Fellow in Cancer Biology, University of Michigan, Ann Arbor

　　·         University of Michigan

　　·         Location: Ann Arbor, MI

　　·         Job Number: 7057183

　　·         Posting Date: May 2, 2019

　　·         Application Deadline: Jul 2, 2019

　　Job Description

　　Description:

　　Postdoctoral position in biomedical science is available in Prof. Jolanta Grembecka laboratory, University of Michigan, Ann Arbor, to carry out an interdisciplinary project to study the effect of small molecules in in vitro and in vivo models of cancers and to pursue target validation studies using genetic approaches. We are seeking for a highly motivated postdoctoral fellow with extensive experience in cancer cell biology. The research will be focused on evaluation of the activity and the mechanism of action of novel small molecules blocking epigenetic proteins in cancer. This position requires the expertise in cell biology and molecular biology techniques, including PCR, qRT-PCR, Western Blotting, co-Immunoprecipitation, ChIP, ChIPSeq, flow cytometry, fluorescence microscopy, immunostaining. Prior work experience with animals such as transgenic mice and xenograft models of cancer would be desired. Successful candidate will be a part of an interdisciplinary team focused on development and pre-clinical evaluation of novel anti-cancer drug candidates.

　　Requirements:

　　Applicant must have PhD in biology or related field. The candidates must be a first author on at least 2-3 publications. This position requires extensive experience in cell and molecular biology techniques. Furthermore, excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations.

　　How to apply:

　　Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: jolantag@umich.edu.

　　Contact:

　　Jolanta Grembecka, PhD, Associate Professor

　　Department of Pathology, University of Michigan

　　Ann Arbor, MI, 48109, USA

　　https://www.pathology.med.umich.edu/index.php?t=page&id=1473

　　e-mail: jolantag@umich.edu

　　Relevant publications:

　　1. Borkin, D. et al., Grembecka, J., Pharmacologic inhibition of the menin-MLL interaction blocks progression of

　　MLL leukemia in vivo, Cancer Cell, 2015, 27 (4), 589-602.

　　2. He S, et; al., Grembecka J., Menin-MLL inhibitors block oncogenic transformation by MLL fusion proteins in a

　　fusion partner independent manner. Leukemia. 2016 Feb;30(2):508-13.

　　3. Kempinska K, et al, Grembecka J: Pharmacologic inhibition of the menin-MLL interaction leads to

　　transcriptional repression of PEG10 and blocks hepatocellular carcinoma. Mol Cancer Ther: 2018 Jan;17(1):26-

　　38.

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