招聘簡(jiǎn)介：

　　博士后研究員

　　·德州大學(xué)安德森癌癥中心

　　·地點(diǎn)：德克薩斯州休斯頓

　　·工作編號(hào)：7058190

　　·發(fā)布日期：2019年6月25日

　　·申請(qǐng)截止日期：開放至填寫

　　工作描述

　　我們正在尋找一個(gè)在腫瘤免疫學(xué)和癌細(xì)胞生物學(xué)方面具有技術(shù)專長的創(chuàng)新性和積極性的人來進(jìn)行一個(gè)雄心勃勃的項(xiàng)目，目標(biāo)是白血病細(xì)胞中的免疫檢測(cè)點(diǎn)蛋白。理想的候選人將擁有生命科學(xué)博士學(xué)位，如細(xì)胞生物學(xué)或分子生物學(xué)，具有研究經(jīng)驗(yàn)，并在細(xì)胞生物學(xué)、腫瘤免疫學(xué)和與腫瘤間質(zhì)相互作用有關(guān)的信號(hào)傳導(dǎo)過程方面擁有優(yōu)秀的知識(shí)庫。有白血病、T細(xì)胞和NK細(xì)胞原代培養(yǎng)、定量測(cè)量RNA表達(dá)、流式細(xì)胞術(shù)、人源化單克隆抗體、大數(shù)據(jù)分析和/或使用動(dòng)物模型的經(jīng)驗(yàn)者優(yōu)先。申請(qǐng)人應(yīng)享受為學(xué)生和其他同事提供培訓(xùn)的角色，并應(yīng)在大型研究小組內(nèi)開放進(jìn)行科學(xué)合作。應(yīng)聘者應(yīng)具備良好的書面和口頭（英語）溝通能力。

　　英文原文：

　　Postdoctoral Fellow

　　·         The University of Texas M. D. Anderson Cancer Center

　　·         Location: Houston, TX

　　·         Job Number: 7058190

　　·         Posting Date: Jun 25, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　We are looking for an innovative and motivated individual with technical expertise in tumor immunology and cancer cell biology to conduct a highly ambitious project targeting immune-checkpoint proteins in leukemia cells. The ideal candidate will possess a PhD degree in a life science, like cellular or molecular biology, with research experience and an excellent knowledge-base in cell biology, tumor immunology, and signaling process as they relate to tumor-stroma interactions. Experience in leukemia, primary cell culture of T cells and NK cells, the quantitative measurement of RNA expression, flow cytometry, humanized monoclonal antibodies, big data analysis, and/or the use of animal models would be a plus. The applicant should enjoy providing a training role for students and other coworkers, and should be open to scientific collaboration within a large research group. The candidate should possess excellent written and spoken (English) communication skills.

　　The task: Development of monoclonal antibodies to target immune checkpoint proteins in leukemia cells through series of immune cell mediated cytotoxicity assays such as chromium release assay, apoptosis and cell death assays. The ultimate goal of this project is to develop therapeutic (chimeric/fully humanized) antibodies to target immune checkpoint proteins that are overexpressed in leukemia cells. The postdoctoral fellow will collaborate with related investigators in an interdisciplinary research project that involves basic cell culture, flow cytometry/sorting, immune cell mediated cytotoxicity assays, DNA/RNA isolation/analysis, and the use of immuno-competent/deficient mouse models. The postdoctoral fellow will present relevant scientific findings at project meetings, National and international conferences, and via publication in top-tier scientific publications.

　　Interested candidates should email their CV to Dr. Batula at: vbattula@mdanderson.org with a subject line stating “Postdoctoral position-2 in your laboratory”

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