美國(guó)芝加哥大學(xué)控制心律、功能和疾病的基因調(diào)控網(wǎng)絡(luò)研究博士后職位招聘

　　Postdoctoral Scholar for the Study of Gene Regulatory Networks Controlling Cardiac Rhythm, Function, and Disease

　　·         University of Chicago

　　·         Location: Chicago, IL

　　·         Job Number: 7062376

　　·         Posting Date: Nov 15, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　What are the genomic principals of the gene regulatory networks that control cardiac

　　rhythm and function in the adult heart? How do perturbation of these networks cause

　　arrhythmias or heart failure? Can we define pathologic networks specific to disease

　　and intervene to improve cardiac rhythm or heart function?

　　Applications are invited for postdoctoral positions for research and training in the

　　Moskowitz laboratory at The University of Chicago to investigate these questions

　　(http://moskowitzlab.uchicago.edu/index.html). We seek a motivated and well-trained

　　individual to join a NIH funded investigation of the gene regulatory networks controlling

　　heart rhythm and arrhythmias (https://elifesciences.org/articles/31683 and

　　https://stm.sciencemag.org/content/8/354/354ra115). We have pioneered a novel

　　approach for identification of functional enhancers and associated long non-coding

　　RNAs (lncRNAs). We will investigate the gene regulatory networks controlling cardiac

　　rhythm and function, and define the molecular mechanisms underlying cardiac

　　arrhythmias and heart failure that result from network dysfunction. These novel

　　approaches are applicable to human genetics, transcriptional regulation, and RNA

　　biology, and will impact cardiovascular genetics and human molecular

　　genetics more broadly. The laboratory integrates genomics, bioinformatics, molecular biology, mouse genetics, human genetics, and embryonic stem cell differentiations to investigate basic principles of gene regulation in the context of the adult heart.

　　Our laboratory is affiliated with the Departments of Pediatrics, Pathology, and Human

　　Genetics, the Institute for Genomics and Systems Biology (http://www.igsb.org), and

　　graduate programs in both Development, Regeneration and Stem Cell Biology

　　(https://drsb.uchicago.edu) and Genetics, Genomics and Systems Biology

　　(https://ggsb.uchicago.edu). We are located in the Knapp Center at the University of

　　Chicago.

　　Highly motivated candidates with a recent PhD in developmental biology, molecular

　　biology, genetics, pathology, cardiology or related fields and with at least one first author paper in an English language journal are encouraged to apply. Experience with

　　genomics, molecular biology, mouse genetics, and/or bioinformatics is sought.

　　Molecular biology skills are essential. Please send a letter describing research

　　experience/interest, CV, and contact information for three references electronically to:

　　cpaez@peds.bsd.uchicago.edu.

　　Please address correspondence to:

　　Ivan Moskowitz, M.D., Ph.D.

　　Professor and Vice Chair for Research

　　Departments of Pediatrics and Pathology

　　The University of Chicago

　　900 East 57th Street, KCBD Room 5102

　　Chicago, Illinois 60637

　　Key words: Genetics, Genomics, Heart, Cardiac, Cardiac Rhythm, Arrhythmia, Atrial Fibrillation, Cardiac Function, Heart Failure, electrophysiology, RNA, non-coding RNA, long non-coding RNA, lncRNA, cardiology, molecular mechanism, gene regulatory network

　　The University of Chicago is an Affirmative Action/Equal Opportunity Employer.

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